There are a "bumper crop" of important security updates for Windows, MS/Office, and IE this month.   I've installed these at work and so far so good.  The ISC link should be monitored for any developments of exploits or installation issues related to these important updates.

http://www.microsoft.com/technet/security/bulletin/ms08-feb.mspx
http://isc.sans.org/diary.html?storyid=3973

Microsoft is releasing the following eleven new security bulletins for newly discovered vulnerabilities:
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Bulletin Number: MS08-003
Maximum Severity: Important
Affected Products: Windows 2000, Windows XP, Windows Server 2003
Impact: Denial of Service
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Bulletin Number: MS08-004
Maximum Severity: Important
Affected Products: Windows Vista
Impact: Denial of Service
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Bulletin Number: MS08-005
Maximum Severity: Important
Affected Products: Windows 2000, Windows XP, Windows Server 2003,
 Windows Vista
Impact: Elevation of Privilege
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Bulletin Number: MS08-006
Maximum Severity: Important
Affected Products: Windows XP, Windows Server 2003
Impact: Remote Code Execution
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Bulletin Number: MS08-007
Maximum Severity: Critical
Affected Products: Windows XP, Windows Server 2003, Windows Vista
Impact: Remote Code Execution
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Bulletin Number: MS08-008
Maximum Severity: Critical
Affected Products: Windows 2000, Windows XP, Windows Server 2003,
 Windows Vista, Office 2004 for Mac, and Visual Basic 6.0
Impact: Remote Code Execution
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Bulletin Number: MS08-009
Maximum Severity: Critical
Affected Products: Office 2000 SP3, Office XP SP3, Office 2003 SP2
Impact: Remote Code Execution
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Bulletin Number: MS08-010
Maximum Severity: Critical
Affected Products: All IE on Windows 2000, Windows XP, Windows Server
 2003, and Windows Vista
Impact: Remote Code Execution
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Bulletin Number: MS08-011
Maximum Severity: Important
Affected Products: Office 2003 SP2, Office 2003 SP3, Works 8.0, and
 Works Suite 2005
Impact: Remote Code Execution
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Bulletin Number: MS08-012
Maximum Severity: Critical
Affected Products: Office 2000 SP3, Office XP SP3, and Office 2003 SP2
Impact: Remote Code Execution
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Bulletin Number: MS08-013
Maximum Severity: Critical
Affected Products: Office 2000 SP3, Office XP SP3, and Office 2003 SP2,
 Office 2004 for Mac
Impact: Remote Code Execution